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FMD Situation in the Far East - 2010 |
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01-May-2010: In a
letter to the Veterinary Record,
Paton et al. (2010)
highlighted the unusual recent
spread of FMD in the Far East
and warned of the possibility of
disease spread both within and
outside the region, as happened
during the FMD O PanAsia
pandemic of 1999-2001 (Knowles
et al., 2001; Knowles
et al., 2005). |
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08-May-2010: FMDV type O, Southeast Asia (SEA) topotype, Mya-98
lineage, has now been confirmed in
Hong Kong SAR,
Republic of Korea and
Japan.
The first outbreak of FMD O to
occur on mainland
China (Guangdong province) has also
been confirmed to belong to the
SEA topotype (Li, 2010). The
genetic identity of the recent
outbreak of type O in
Mongolia has yet
to be determined. |
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14-May-2010: At the
FAO/OIE Reference Laboratory for
FMD at the Institute for Animal
Health (UK) we have determined
the full genome sequence for a
representative serotype O
isolate recovered from the
recent outbreaks of FMD that
have occurred in the Far East
(Hamid et al.,
unpublished data). The full
genome sequence (8123
nucleotides) was generated from
an isolate obtained from a pig
with epithelial lesions that was
sampled in Hong Kong SAR on
03/03/2010. This sequence has
been submitted to the public
databases and a
draft version of this sequence
is available here (accession
number HM229661).
During
previous FMD outbreaks in the UK
(2001 and 2007), full genome
sequence data has been used to
reconstruct transmission
pathways at the farm-to-farm
level: for examples see Cottam
et al., 2006 and Cottam
et al., 2008. This
approach could be used now to
support epidemiological
investigations that are being
conducted to understand the
regional and local spread of the
virus in Asia. This
sequence can also be used to
check the suitability of
molecular tests used for the
diagnosis of FMD in the region.
Further
information, including detailed
laboratory RT-PCR protocols used
to generate these sequences, can
be obtained from
faizah.hamid@bbsrc.ac.uk or
donald.king@bbsrc.ac.uk.
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References |
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Cottam et al.,
(2006) Molecular Epidemiology of
Foot-and-mouth disease virus
outbreak in the United Kingdom.
Journal of Virology 80: 11274.
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Cottam et
al., (2008) Transmission
pathways of foot-and-mouth
disease virus in the United
Kingdom in 2007. PLoS Pathogens
4: e1000050. |
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Hamid, F.N.,
Wadsworth, J., Knowles, N.J. and
King, D.P. Full genome sequence
of FMDV (serotype O) in Hong
Kong (2010). Unpublished. |
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Knowles,
N.J., Samuel, A.R., Davies,
P.R., Kitching, R.P. and
Donaldson, A.I. (2001). Outbreak
of foot‑and‑mouth disease virus
serotype O in the UK caused by a
pandemic strain. Veterinary
Record 148: 258-259. |
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Knowles,
N.J., Samuel, A.R., Davies,
P.R., Midgley, R.J. and
Valarcher, J.-F. (2005).
Evolution and spread of a
pandemic strain of
foot-and-mouth disease virus
serotype O. Emerging Infectious
Diseases 11: 1887-1893. |
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Li, J.
(2010). Situation and control of
FMD in mainland, China. 16th OIE
Sub-Commission Meeting for FMD
Control in South East Asia,
Vientiane, Lao PDR, 15-19 March
2010. |
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Paton DJ, King DP, Knowles NJ and Hammond J. (2010). Recent
spread of foot-and-mouth disease in the Far East.
Veterinary Record
166: 569-570. |
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© The Pirbright Institute, 2011
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